Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis
Arq. neuropsiquiatr
;
61(4): 897-901, Dec. 2003. tab
Artículo
en Inglés
| LILACS
| ID: lil-352421
ABSTRACT
Convulsions triggered by fever are the most common type of seizures in childhood, and 20 percent to 30 percent of them have recurrence. The prophylactic treatment is still controversial, so we performed a systematic review to find out the effectiveness of continuous phenobarbital and intermittent diazepam compared to placebo for febrile seizure recurrence. METHOD:
Only randomized, double-blind, placebo-controlled trials were analyzed. The recurrence of febrile seizure was assessed for each drug.RESULTS:
Ten eligible clinical trials were included. Febrile seizure recurrence was smaller in children treated with diazepam or phenobarbital than in placebo group. Prophylaxis with either phenobarbital or diazepam reduces recurrences of febrile seizures. The studies were clinical, methodological, and statistically heterogeneous.CONCLUSION:
The effectiveness of phenobarbital and diazepam could not be demonstrated because clinical trials were heterogeneous, and the recommendation for treatment recurrence should rely upon the experience of the assistant physician yet
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Fenobarbital
/
Convulsiones Febriles
/
Diazepam
/
Anticonvulsivantes
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio de etiología
/
Guía de Práctica Clínica
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
/
Revisiones Sistemáticas Evaluadas
Límite:
Humanos
Idioma:
Inglés
Revista:
Arq. neuropsiquiatr
Asunto de la revista:
Neurología
/
Psiquiatria
Año:
2003
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Federal University of São Paulo/BR
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