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Clinical presentation and follow up of children with congenital toxoplasmosis in Brazil
Sáfadi, Marco A. P; Berezin, Eitan N; Farhat, Calil K; Carvalho, Eduardo S.
  • Sáfadi, Marco A. P; Santa Casa de São Paulo School of Medical Sciences. Division of Pediatric Infectious Diseases. São Paulo. BR
  • Berezin, Eitan N; Santa Casa de São Paulo School of Medical Sciences. Division of Pediatric Infectious Diseases. São Paulo. BR
  • Farhat, Calil K; Santa Casa de São Paulo School of Medical Sciences. Division of Pediatric Infectious Diseases. São Paulo. BR
  • Carvalho, Eduardo S; Santa Casa de São Paulo School of Medical Sciences. Division of Pediatric Infectious Diseases. São Paulo. BR
Braz. j. infect. dis ; 7(5): 325-331, Oct. 2003. tab
Artículo en Inglés | LILACS, SES-SP | ID: lil-354282
RESUMO
We evaluated the clinical presentation and determined the ocular and neurologic sequelae in children with congenital toxoplasmosis in Brazil, taking into consideration the shortage of national publications on this disease. Follow-up evaluations were made of 43 children with congenital toxoplasmosis referred to Santa Casa de São Paulo, during a period of at least five years. Selection of the cases was based in clinical and laboratory criteria. A clear predominance of children with subclinical presentation of the disease at birth (88 percent) was found. Of the 43 children, 22 (51 percent) developed neurological manifestations. Using skull radiography, we detected neuroradiologic alterations in seven children (16 percent) and with tomography in 33 children (77 percent). Neurological sequelae were identified in 15 children (54 percent) in the group with cerebral calcifications and in 7 (47 percent) in the group without cerebral calcifications. We observed chorioretinitis in 95 percent of the cases. Reactivation of cicatricial lesions and the emergence of new ocular lesions were observed in five cases. The most frequent neurological manifestation was a delay in neuropsychomotor development. Most remarkable was the finding that cerebral calcifications were not associated with a higher incidence of neurological sequelae among the children. Chorioretinitis was the main ocular sequel of the infection, found in nearly all children; it can manifest years from birth, even in children submitted to specific therapy during the first year of life, highligh.ting the importance of a follow-up of these children
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Encefalopatías / Calcinosis / Toxoplasmosis Congénita / Oftalmopatías Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Child, preschool / Femenino / Humanos / Lactante / Masculino / Recién Nacido País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Braz. j. infect. dis Año: 2003 Tipo del documento: Artículo Institución/País de afiliación: Santa Casa de São Paulo School of Medical Sciences/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Encefalopatías / Calcinosis / Toxoplasmosis Congénita / Oftalmopatías Tipo de estudio: Estudio de etiología / Estudio observacional / Estudio pronóstico / Factores de riesgo Límite: Child, preschool / Femenino / Humanos / Lactante / Masculino / Recién Nacido País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Braz. j. infect. dis Año: 2003 Tipo del documento: Artículo Institución/País de afiliación: Santa Casa de São Paulo School of Medical Sciences/BR