Comparison of the homeostasis model assessment and quantitative insulin sensitivity check index with data from forearm metabolic studies for the in vivo assessment of insulin sensitivity
Braz. j. med. biol. res
;
37(5): 663-668, May 2004. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-357549
RESUMO
The present study was designed to compare the homeostasis model assessment (HOMA) and quantitative insulin sensitivity check index (QUICKI) with data from forearm metabolic studies of healthy individuals and of subjects in various pathological states. Fifty-five healthy individuals and 112 patients in various pathological states, including type 2 diabetes mellitus, essential hypertension and others, were studied after an overnight fast and for 3 h after ingestion of 75 g of glucose, by HOMA, QUICKI and the forearm technique to estimate muscle uptake of glucose combined with indirect calorimetry (oxidative and non-oxidative glucose metabolism). The patients showed increased HOMA (1.88 ñ 0.14 vs 1.13 ñ 0.10 pmol/l x mmol/l) and insulin/glucose (I/G) index (1.058.9 ñ 340.9 vs 518.6 ñ 70.7 pmol/l x (mg/100 ml forearm)-1), and decreased QUICKI (0.36 ñ 0.004 vs 0.39 ñ 0.006 (æU/ml + mg/dl)-1) compared with the healthy individuals. Analysis of the data for the group as a whole (patients and healthy individuals) showed that the estimate of insulin resistance by HOMA was correlated with data obtained in the forearm metabolic studies (glucose uptake r = -0.16, P = 0.04; non-oxidative glucose metabolism r = -0.20. P = 0.01, and I/G index r = 0.17, P = 0.03). The comparison of QUICKI with data of the forearm metabolic studies showed significant correlation between QUICKI and non-oxidative glucose metabolism (r = 0.17, P = 0.03) or I/G index (r = -0.37, P < 0.0001). The HOMA and QUICKI are good estimates of insulin sensitivity as data derived from forearm metabolic studies involving direct measurements of insulin action on muscle glucose metabolism.
Texto completo:
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Índice:
LILACS (Américas)
Asunto principal:
Glucemia
/
Resistencia a la Insulina
/
Técnica de Clampeo de la Glucosa
/
Homeostasis
Tipo de estudio:
Estudio diagnóstico
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
2004
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de São Paulo/BR
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