Pancreatic capillary blood flow during caerulein-induced pancreatitis evaluated by a laser-doppler flowmeter in rats
Acta cir. bras
;
18(supl.5): 18-22, 2003. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-358577
ABSTRACT
Purpose:
The pancreatic capillary blood flow (PCBF) was studied to determine its alterations during caerulein-induced pancreatitis in rats.Methods:
Twenty rats were divided in groups control and caerulein. A laser-Doppler flowmeter to measure PCBF continuously was used. Blood pressure (BP) and heart rate (HR) were monitored. Serum biochemistry analyses were determined. Histopathological study was performed.Results:
The PCBF measured a mean of 109.08 ± 14.54 percent and 68.24 ± 10.47 percent in control group and caerulein group, respectively. Caerulein group had a mean decrease of 31.75 ± 16.79 percent. The serum amylase was 1323.70 ± 239.l0U.I-1 and 2184.60 ± 700.46U.I-1 in control and caerulein groups, respectively. There was a significant difference in the PCBF (p<0.05) and serum amylase (p<0.05) when compared to control and caerulein groups. Although micro and microvacuolization were seen in 30 percent in caerulein group, no significant difference was seen between the groups.Conclusion:
A decrease in the PCBF may be one of the leading events and it is present before histopathological tissue injury had been established in this model of acute pancreatitis.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Páncreas
/
Pancreatitis
/
Ceruletida
/
Flujometría por Láser-Doppler
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2003
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Estados Unidos
Institución/País de afiliación:
Cornell University Medical College/US
/
Faculdade de Medicina de São José do Rio Preto/BR
/
Universidade de São Paulo/BR
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