Evaluacion de la capacidad inmunogénica de la vacuna antirrábica tipo Fuenzalida- Palacios (CRL) y de la vacuna antirrábica de cultivo celular (Verorab½) en personas con tratamiento preexposición / Immune response of suckling mouse brain (CRL) rabies vaccine and tissue culture rabies vaccine (Verorab½) in pre-exposure prophylaxis in humans
Rev. méd. Chile
;
132(1): 41-46, ene. 2004. tab
Artículo
en Español
| LILACS
| ID: lil-359177
ABSTRACT
Background:
A WHO experts committee recommended the substitution of antirabic vaccines produced in nervous tissue, by vaccines produced in tissue cultures.Aim:
To compare the immunogenic capacity of antirabic vaccines CRL (produced in nervous tissue) and Verorab½ (produced in tissue culture), used for pre-exposure prophylaxis in humans. Patients andmethods:
Fifty four volunteers were immunized for this study. The first group, vaccinated with CLR was treated with a scheme of 4 subcutaneous peri umbilical doses in days 0, 3, 7 and 28. The second group, vaccinated with Verorab½ vaccine was treated with a scheme of 3 intramuscular doses in deltoid zone at days 0, 7 and 28. Blood samples were obtained at days 0, 7, 42 and 365 to measure neutralizing antibodies using the Inhibition of Fluorescent Focus Technique (RFFIT).Results:
At day seven, a primary non protective immunologic response was observed in both groups, with titers significantly higher in the group vaccinated with Verorab½. At day 42, no differences were observed. At day 365, all subjects vaccinated with Verorab½ and 50 percent of individuals vaccinated with CRL had protective antibody titers (p <0,05).Conclusions:
The vaccine produced in cell breeds (Verorab½) produces a better an faster immunologic response compared to the CRL vaccine (Rev Méd Chile 2004; 132 41-6).
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Vacunas Antirrábicas
Límite:
Adulto
/
Humanos
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2004
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Chile
/
Cuba
Institución/País de afiliación:
Instituto de Salud Pública/CL
/
Universidad Santo Tomás/CL
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