Ligation of the abdominal esophagus decreases scorpion toxin-induced gastric secretion in rats
Acta cir. bras
;
19(3): 168-174, May-June 2004. tab
Artículo
en Inglés
| LILACS
| ID: lil-362021
ABSTRACT
PURPOSE:
Scorpion toxin purified from Tityus serrulatus venom (Tx) induces an increase in volume, acidity and pepsin secretion in the gastric juice of rats. Ligation of oesophagus has been shown to reduce the acid gastric secretion in rats. The aim of this paper was to determine the influence of the esophageal ligation on gastric secretion induced by Tx in rats.METHODS:
Forty-four male albino rats were given water ad libitum, but no food for 20 to 24 hours, anesthetized with urethane and the trachea and jugular vein cannulated. Cervical or abdominal esophageal ligation or sham-operations were performed before and after the injection of 0.25 mg/kg of scorpion toxin (fraction Tl) into the jugular vein. One hour later, the volume, acidity, pH and peptic activity of gastric juice were determined.RESULTS:
The scorpion toxin induced an increase in gastric juice volume, acidity and pepsin output and a decrease in pH when injected into the vein of intact animals or in sham-operated animals. Cervical esophagus ligation did not interfere with the effects of toxin, however, ligation of the abdominal esophageal decreased the toxin effect on the rat stomach.CONCLUSION:
Ligation of the abdominal esophagus decreases the gastric secretion induced by scorpion toxin.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Venenos de Escorpión
/
Pepsina A
/
Esófago
/
Jugo Gástrico
Límite:
Animales
Idioma:
Inglés
Revista:
Acta cir. bras
Asunto de la revista:
Cirugía General
/
Procedimentos Cir£rgicos Operat¢rios
Año:
2004
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Faculty of Medicine São Paulo University/BR
/
Federal University of Minas Gerais/BR
/
State University of Campinas/BR
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