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Aminotransferase changes and acute hepatitis in patients with dengue fever: analysis of 1, 585 cases
Souza, Luiz José de; Alves, José Galvão; Nogueira, Rita Maria Ribeiro; Gicovate Neto, Carlos; Bastos, Diogo Assed; Siqueira, Edno Wallace da Silva; Souto Filho, João Tadeu Damian; Cezário, Thiago de Abreu; Soares, Carlos Eduardo; Carneiro, Rodrigo da Costa.
  • Souza, Luiz José de; Dengue Reference Center. BR
  • Alves, José Galvão; The Brazilian Society of Internal Medicine. Campos dos Goytacazes. BR
  • Nogueira, Rita Maria Ribeiro; FIOCRUZ. Oswaldo Cruz Institute. Department of Virology. Rio de Janeiro. BR
  • Gicovate Neto, Carlos; Dengue Reference Center. BR
  • Bastos, Diogo Assed; Dengue Reference Center. BR
  • Siqueira, Edno Wallace da Silva; Dengue Reference Center. BR
  • Souto Filho, João Tadeu Damian; Dengue Reference Center. BR
  • Cezário, Thiago de Abreu; Dengue Reference Center. BR
  • Soares, Carlos Eduardo; Dengue Reference Center. BR
  • Carneiro, Rodrigo da Costa; Dengue Reference Center. BR
Braz. j. infect. dis ; 8(2): 156-163, Apr. 2004. ilus, tab
Artículo en Inglés | LILACS | ID: lil-365409
RESUMO

INTRODUCTION:

Type 3 dengue virus caused an extensive epidemic in the state of Rio de Janeiro in summer 2002. In some of the patients, it was found in an atypical form with increased aminotransferase levels and acute hepatitis. MATERIAL AND

METHODS:

An analysis was made of 1,585 serologically confirmed dengue cases at the Dengue Reference Center in Campos dos Goytacazes, Rio de Janeiro state. The grade of hepatic aggression was established according to the alterations in the aminotransferase levels grade A - normal levels of aminotransferase; grade B - elevated aminotransferase, with increased levels of at least one of the enzymes; grade C - elevated aminotransferase, with the levels of at least one of the enzymes increased to more than three times the reference values; grade D - acute hepatitis, with aminotransferase levels increased to at least 10 times their normal values.

RESULTS:

Among the 1,585 serologically confirmed dengue cases, 44.5 percent presented alterations in the aminotransferase levels (grade B), 16.9 percent presented grade C liver involvement and 3.8 percent of the patients had progressed to acute hepatitis (grade D). The average values for the rise in aspartate aminotransferase and alanine aminotransferase were 93.3 U/L and 86.0 U/L. The greatest alterations were observed among females (p<0.001), cases of dengue hemorrhagic fever (p<0.001), and cases with sequential infections (p=0.001).

CONCLUSIONS:

Liver damage with elevation of aminotransferases and reactive hepatitis was a common complication of dengue virus infection in these patients.
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Dengue / Virus del Dengue / Transaminasas / Hepatitis Tipo de estudio: Estudio pronóstico Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Braz. j. infect. dis Asunto de la revista: Enfermedades Transmisibles Año: 2004 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Dengue Reference Center/BR / FIOCRUZ/BR / The Brazilian Society of Internal Medicine/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Dengue / Virus del Dengue / Transaminasas / Hepatitis Tipo de estudio: Estudio pronóstico Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Braz. j. infect. dis Asunto de la revista: Enfermedades Transmisibles Año: 2004 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Dengue Reference Center/BR / FIOCRUZ/BR / The Brazilian Society of Internal Medicine/BR