Aminotransferase changes and acute hepatitis in patients with dengue fever: analysis of 1, 585 cases
Braz. j. infect. dis
;
8(2): 156-163, Apr. 2004. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-365409
RESUMO
INTRODUCTION:
Type 3 dengue virus caused an extensive epidemic in the state of Rio de Janeiro in summer 2002. In some of the patients, it was found in an atypical form with increased aminotransferase levels and acute hepatitis. MATERIAL ANDMETHODS:
An analysis was made of 1,585 serologically confirmed dengue cases at the Dengue Reference Center in Campos dos Goytacazes, Rio de Janeiro state. The grade of hepatic aggression was established according to the alterations in the aminotransferase levels grade A - normal levels of aminotransferase; grade B - elevated aminotransferase, with increased levels of at least one of the enzymes; grade C - elevated aminotransferase, with the levels of at least one of the enzymes increased to more than three times the reference values; grade D - acute hepatitis, with aminotransferase levels increased to at least 10 times their normal values.RESULTS:
Among the 1,585 serologically confirmed dengue cases, 44.5 percent presented alterations in the aminotransferase levels (grade B), 16.9 percent presented grade C liver involvement and 3.8 percent of the patients had progressed to acute hepatitis (grade D). The average values for the rise in aspartate aminotransferase and alanine aminotransferase were 93.3 U/L and 86.0 U/L. The greatest alterations were observed among females (p<0.001), cases of dengue hemorrhagic fever (p<0.001), and cases with sequential infections (p=0.001).CONCLUSIONS:
Liver damage with elevation of aminotransferases and reactive hepatitis was a common complication of dengue virus infection in these patients.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Dengue
/
Virus del Dengue
/
Transaminasas
/
Hepatitis
Tipo de estudio:
Estudio pronóstico
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2004
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Dengue Reference Center/BR
/
FIOCRUZ/BR
/
The Brazilian Society of Internal Medicine/BR
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