Reversibilidad espirométrica en la enfermedad pulmonar obstructiva crónica: efecto diferencial del salbutamol sobre el volumen espiratorio forzado del primer segundo y el volumen pulmonar / Spirometric reversibility to Salbutamol in chronic obstructive pulmonary disease (COPD): differential effects on FEV1 and on lung volumes
Rev. méd. Chile
;
132(7): 787-793, jul. 2004. tab, graf
Artículo
en Español
| LILACS
| ID: lil-366577
ABSTRACT
Background:
In recent years it has been suggested that in COPD, lung volumes can be modified more than expiratory flows, with bronchodilators.Aim:
To study the acute effects of salbutamol on FEV1 and lung volumes at rest. Subjects andMethods:
Forty stable COPD patients were studied using a single dose of salbutamol (200 µg). Forced expiratory volumen in 1 second (FEV1), slow vital capacity (SVC), forced vital capacity (FVC), and inspiratory capacity (IC) were measured at baseline and after salbutamol administration.Results:
After salbutamol, 39/40 patients exhibited a clinically significant increase in volumes (SVC, FVC or IC ×10 percent predicted). A significant increase in FEV1 (×10 percent predicted) was observed in only 13 patients.Conclusions:
Our results demonstrate that changes in lung volumes, and consequently in dynamic lung hyperinflation, take place more frequently than changes in maximal expiratory flows during the spirometric test in patients with COPD. Assessment of spirometric reversibility based only on changes in FEV1 underestimates the effect of bronchodilator drugs in these patients.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Broncodilatadores
/
Volumen Espiratorio Forzado
/
Albuterol
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2004
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Chile
Institución/País de afiliación:
Pontificia Universidad Católica de Chile/CL
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