Cytokine profile associated with human chronic schistosomiasis mansoni
Mem. Inst. Oswaldo Cruz
;
99(5,supl.1): 21-26, Aug. 2004. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-384474
RESUMO
This study objective was to evaluate the cytokines associated with early events of hepatic fibrosis in schistosomiasis mansoni. Hepatic fibrosis was classified by ultrasonography in 94 patients. Immunological evaluation was performed by measurement of secreted cytokines (interleukin IL-5, IL-10, IL-13, interferon-gamma, tumor necrosis factor-alpha and transforming growth factors-beta) in peripherl blood mononuclear cells stimulated by Schistosoma mansoni antigens. Significantly, higher levels of IL-5, IL-10 and IL-13 were found in supernatants of SEA-stimulated PBMC from subjects with degree III hepatic fibrosis as compared to patients with degree I or II fibrosis, Significant increases in IL-5 and IL-13 levels were also observed in some of the subjects who remained untreated for one year following initial assessment and developed more serious fibrosis during this period. The data suggests a role for type 2 cytokines in early stages of hepatic fibrosis in human schistosomiasis mansoni.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Schistosoma mansoni
/
Esquistosomiasis mansoni
/
Leucocitos Mononucleares
/
Citocinas
/
Cirrosis Hepática
Tipo de estudio:
Factores de riesgo
Límite:
Animales
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2004
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
/
Estados Unidos
Institución/País de afiliación:
Clínica Gonzalez Miranda Ltda/BR
/
Universidade Federal da Bahia/BR
/
Universidade Federal de Sergipe/BR
/
University of Pennsylvania/US
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