Actions of mefenamic acid on pregnant albino rats
Int. j. morphol
;
20(2): 169-173, 2002. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-388078
RESUMO
Misuse and abuse of the non-steroidal anti-inflammatory and analgesic mefenamic acid among pregnant women in developing coutries constitute a matter of medical concern, mainly as a function of the potentially serious side effects of that drug, notably at the digestive system level. Female rats were treated during the entire pregnancy period (from day 0 up to day 20) with 5, 15, or 45 mg/kg of mefenamic acid (MA) once daily, by gavage. Controls received the drug vehicle. We observed that there was a slight yet significant impairment of maternal body weight gain of the animals treated with the two highest doses of MA. Although the drug was proven to exert deleterious effects on kidney and liver metabolic functions, no gross signs of renal or hepatic toxicity were detected in our animals and in their concepts. The digestive effects would be presumably caused by the inhibitory actions of MA on the luminal fluid movement and are accounted for by the observed body weight loss during pregnancy.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Preñez
/
Ácido Mefenámico
/
Antiinflamatorios
Límite:
Animales
Idioma:
Inglés
Revista:
Int. j. morphol
Asunto de la revista:
Anatomía
Año:
2002
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Fundação ABC/BR
/
Universidade Federal de São Paulo/BR
/
Universidade de São Paulo/BR
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