What is the probability of a patient presenting a pleural effusion due to tuberculosis?
Braz. j. infect. dis
;
8(4): 311-318, Aug. 2004. ilus, tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-389478
RESUMO
INTRODUCTION:
In Rio de Janeiro, in almost half of the cases of pleural tuberculosis (PT) treatment begins without substantiation of diagnosis. We examined variables associated with this disease.METHOD:
We studied 215 consecutive patients; 104 had tuberculosis (TB) and 111 did not (NTB) 41 neoplasms, 29 transudates, 28 para-pneumonic and 13 other etiologies. Clinical and laboratory variables were assessed in a combined manner using likelihood ratios (LR) and Bayes' theorem to determine the probability of PT.RESULTS:
Among the variables examined, adenosine deaminase (ADA) levels, lymphocyte cell percentage, protein and age were the best indicators for the diagnosis of PT. Association of ADA with any of the other variables led to a LR+ higher than 10 and a LR- lower than 0.1, indicating the presence or absence of PT, with an individual probability of more than 90 percent or of less than 10 percent considering that there was a 50 percent initial probability associated with the presence of PT.CONCLUSIONS:
Since ADA is highly sensitive, we can practically exclude TB as the cause of effusion when there are low ADA values. However, to confirm the possibility of TB we recommend that other variables, such as prevalence of lymphocytes (higher than 90 percent), and high protein levels (more than 4g/dL); low age (less than 45 years) also should be considered.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Derrame Pleural
/
Tuberculosis Pleural
/
Proteínas
/
Adenosina Desaminasa
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adulto
/
Humanos
Idioma:
Inglés
Revista:
Braz. j. infect. dis
Asunto de la revista:
Enfermedades Transmisibles
Año:
2004
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Federal University of do Rio de Janeiro/BR
/
University of Rio de Janeiro/BR
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