Analysis of the molecular association of rifampicin with hydroxypropyl-ß-cyclodextrin
RBCF, Rev. bras. ciênc. farm. (Impr.)
;
40(1): 43-51, jan.-mar. 2004. ilus, tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-391011
ABSTRACT
Inclusion complexes of rifampicin (RP) were prepared with hydroxypropyl-ß-cyclodextrin (HPßCD). The aqueous solubility of RP increased linearly with cyclodextrin concentration in all range of the solubility diagram. The data was analyzed using the framework of Higuchi and Connors. The stability constant (K) values for RP/HPßCD complex at pH 6.9 were 18 and 120-125 M-1 for ionic strength 0.01 and 0.18M, respectively. The analysis of the chemical shift data of 1H and 15N for free RP and RP/HPßCD inclusion complex reveal that only peaks of the side chain related to the piperazine ring of RP change substantially, probably due to interaction of this region of RP molecule with the hydrophobic core of HPßCD...
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Rifampin
/
Modelos Moleculares
/
Ciclodextrinas
Tipo de estudio:
Factores de riesgo
Idioma:
Inglés
Revista:
RBCF, Rev. bras. ciênc. farm. (Impr.)
Asunto de la revista:
Bioquímica
/
Farmacia
/
Farmacología
Año:
2004
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Estadual Paulista Júlio de Mesquita Filho/BR
/
Universidade Federal de São Carlos/BR
/
Universidade de São Paulo/BR
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