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Membrane effects of cocoa procyanidins in liposomes and jurkat T cells
Verstraeten, Sandra V; Oteiza, Patricia I; Fraga, César G.
  • Verstraeten, Sandra V; University of Buenos Aires. School of Pharmacy and Biochemistry. Institute of Biochemistry and Biophysics. Department of Biological Chemistry. Buenos Aires. AR
  • Oteiza, Patricia I; University of Buenos Aires. School of Pharmacy and Biochemistry. Institute of Biochemistry and Biophysics. Department of Biological Chemistry. Buenos Aires. AR
  • Fraga, César G; University of Buenos Aires. School of Pharmacy and Biochemistry. Department of Physical Chemistry. Buenos Aires. AR
Biol. Res ; 37(2): 293-300, 2004. ilus, graf
Artículo en Inglés | LILACS | ID: lil-393138
ABSTRACT
We investigated the effects of the interaction between flavanols and related procyanidins (dimer to hexamer) with both cell and synthetic membranes, on bilayer fluidity and susceptibility to oxidation. Cocoa derived dimers (0.05 to 1 µg/ml) protected Jurkat T cells from AMVN-mediated oxidation and increased plasma membrane fluidity. These effects occurred in a concentration- and chain length-dependent manner. In liposomes, procyanidins prevented the Fe²+-induced permeabilization of the membrane. Together, these results support the hypothesis that procyanidins could interact with the polar headgroup of lipids, increasing membrane fluidity and also, preventing the access of molecules that could affect membrane integrity.
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Cacao / Células Jurkat / Liposomas / Antioxidantes Límite: Humanos Idioma: Inglés Revista: Biol. Res Asunto de la revista: Biologia Año: 2004 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Argentina Institución/País de afiliación: University of Buenos Aires/AR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Cacao / Células Jurkat / Liposomas / Antioxidantes Límite: Humanos Idioma: Inglés Revista: Biol. Res Asunto de la revista: Biologia Año: 2004 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Argentina Institución/País de afiliación: University of Buenos Aires/AR