Membrane effects of cocoa procyanidins in liposomes and jurkat T cells
Biol. Res
;
37(2): 293-300, 2004. ilus, graf
Artículo
en Inglés
| LILACS
| ID: lil-393138
ABSTRACT
We investigated the effects of the interaction between flavanols and related procyanidins (dimer to hexamer) with both cell and synthetic membranes, on bilayer fluidity and susceptibility to oxidation. Cocoa derived dimers (0.05 to 1 µg/ml) protected Jurkat T cells from AMVN-mediated oxidation and increased plasma membrane fluidity. These effects occurred in a concentration- and chain length-dependent manner. In liposomes, procyanidins prevented the Fe²+-induced permeabilization of the membrane. Together, these results support the hypothesis that procyanidins could interact with the polar headgroup of lipids, increasing membrane fluidity and also, preventing the access of molecules that could affect membrane integrity.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Cacao
/
Células Jurkat
/
Liposomas
/
Antioxidantes
Límite:
Humanos
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2004
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Argentina
Institución/País de afiliación:
University of Buenos Aires/AR
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