Neonatal rat exposure to pyrethroid and organophosphate insecticides: a physiological and biochemical trial of progeny
Rev. ciênc. farm
;
24(2): 159-167, 2003. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-394858
ABSTRACT
A manufactured product (Ectoplus R) composed by a cypermethrin (44,7 por cento) and dichlorvos (4,2 por cento) mixture was administered (10mg-day, orally, by gavage) to pregnant rats, during the periods of gestation+lactation, gestation, and lactation. Controlmothers received vehicle aqueous solution during the gestation+lactation period. With the progeny, in the 1-15 post-natal days (PND1-15) there were observed alterations in the periods of occurrence of teeth, hair, unfolding of ears, and in the developmental period for following reflexes postural, palmar grasp, negative geotaxis, and acoustic startle reflex. After weaning (PND21), there were observed the presence of cypermethrin and dichlorvos in the blood brain and liver, decrease in weight of liver, of cholinesterase activity in the plasma, liver, and brain, and hepatic metabolizing activity of drugs, alterations of levels of gamma glutamyl transferase enzymes, of creatinine, and of potassium in the serum of the animals. In conclusion, neonatal exposure to a formulated mixture of cypermethrin and dichlorvos is inductive to alterations in characteristics that indicate somatic and neuromuscular development of the progeny, and in certain biochemical parameters. The results suggest that enzymatic assessment associated with somatic and neuromotor assessment can be important markers of developmental characteristics in neonatal toxicity by pesticide formulations based on mixtures of insecticides.
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Índice:
LILACS (Américas)
Asunto principal:
Piretrinas
/
Ratas Wistar
/
Insecticidas Organofosforados
/
Animales Recién Nacidos
Límite:
Animales
/
Embarazo
Idioma:
Inglés
Revista:
Rev. ciênc. farm
Asunto de la revista:
Farmacología
Año:
2003
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Estadual Paulista/BR
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