Analysis of risk factors of involvement of seminal vesicles in patients with prostate cancer undergoing radical prostatectomy
Int. braz. j. urol
; 30(6): 472-478, Nov.-Dec. 2004. tab
Article
en En
| LILACS
| ID: lil-397808
Biblioteca responsable:
BR1.1
ABSTRACT
OBJECTIVE:
To determine through preoperative serum PSA level, Gleason score on biopsy and percentage of fragments affected by tumor on biopsy, the probability of involvement of the seminal vesicles. MATERIALS ANDMETHODS:
During the period between March 1991 to December 2002, we selected 899 patients undergoing radical prostatectomy for treatment of localized prostate adenocarcinoma. The analyzed preoperative variables were PSA, percentage of positive fragments and Gleason score on the biopsy. Pre-operative PSA was divided in scales from 0 to 4.0 ng/mL, 4.1 to 10 ng/mL, 10.1 to 20 ng/mL and > 20 ng/mL, Gleason score was categorized in scales from 2 to 6. 7 and 8 to 10, and the percentage of affected fragments was divided in 0 to 25 percent, 25.1 percent to 50 percent, 50.1 percent to 75 percent, and 75.1 percent to 100 percent. All these variables were correlated with the involvement of seminal vesicles in the surgical specimen.RESULTS:
Of the 899 patients under study, approximately 11 percent (95 percent CI, [9 percent - 13 percent]) had involvement of seminal vesicles. On the multivariate analysis, when PSA was < 4, the Gleason score was 2 to 6, and less than 25 percent of fragments were involved on the biopsy, only 3.6 percent, 7.6 percent and 6.2 percent of patients respectively, had involvement of seminal vesicles. On the multivariate analysis, we observed that PSA, Gleason score and the percentage of involved fragments were independent prognostic factors for invasion of seminal vesicles.CONCLUSION:
The preoperative variables used in the present study allow the identification of men with minimal risk (lower than 5 percent) if involvement of seminal vesicles.
Texto completo:
1
Índice:
LILACS
Asunto principal:
Prostatectomía
/
Neoplasias de la Próstata
/
Vesículas Seminales
Tipo de estudio:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Humans
/
Male
Idioma:
En
Revista:
Int. braz. j. urol
Asunto de la revista:
UROLOGIA
Año:
2004
Tipo del documento:
Article