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Immune response in cervical dysplasia induced by human papillomavirus: the influence of human immunodeficiency virus-1 co-infection - review
Nicol, Alcina Frederica; Fernandes, Ana Teresa Gomes; Bonecini-Almeida, Maria da Gloria.
  • Nicol, Alcina Frederica; Instituto de Pesquisa Clínica Evandro Chagas-Fiocruz. Departamento de Microbiologia, Imunologia e Parasitologia. Serviço de Imunologia. BR
  • Fernandes, Ana Teresa Gomes; Instituto de Pesquisa Clínica Evandro Chagas-Fiocruz. Departamento de Microbiologia, Imunologia e Parasitologia. Serviço de Imunologia. BR
  • Bonecini-Almeida, Maria da Gloria; Instituto de Pesquisa Clínica Evandro Chagas-Fiocruz. Departamento de Microbiologia, Imunologia e Parasitologia. Serviço de Imunologia. BR
Mem. Inst. Oswaldo Cruz ; 100(1): 1-12, Feb. 2005.
Artículo en Inglés | LILACS | ID: lil-398107
RESUMO
Human immunodeficiency virus (HIV-1) has become an important risk factor for human papillomavirus (HPV) infection and the development of HPV associated lesions in the female genital tract. HIV-1 may also increase the oncogenicity of high risk HPV types and the activation of low risk types. The Center for Disease Control and Prevention declared invasive cervical cancer an acquired immunodeficience virus (AIDS) defining illness in HIV positive women. Furthermore, cervical cancer happens to be the second most common female cancer worldwide. The host's local immune response plays a critical factor in controlling these conditions, as well as in changes in the number of professional antigen-presenting cells, cytokine, and MHC molecules expression. Also, the production of cytokines may determine which arm of the immune response will be stimulated and may influence the magnitude of immune protection. Although there are many studies describing the inflammatory response in HPV infection, few data are available to demonstrate the influence of the HIV infection and several questions regarding the cervical immune response are still unknown. In this review we present a brief account of the current understanding of HIV/HPV co-infection, emphasizing cervical immune response.
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Papillomaviridae / Infecciones por VIH / Displasia del Cuello del Útero / Neoplasias del Cuello Uterino / VIH-1 / Infecciones por Papillomavirus Tipo de estudio: Estudio de etiología / Factores de riesgo Límite: Femenino / Humanos Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 2005 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Instituto de Pesquisa Clínica Evandro Chagas-Fiocruz/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Papillomaviridae / Infecciones por VIH / Displasia del Cuello del Útero / Neoplasias del Cuello Uterino / VIH-1 / Infecciones por Papillomavirus Tipo de estudio: Estudio de etiología / Factores de riesgo Límite: Femenino / Humanos Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 2005 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Instituto de Pesquisa Clínica Evandro Chagas-Fiocruz/BR