Human immunodeficiency virus type 1 neutralization by plasma from B or F genotype infected individuals
Mem. Inst. Oswaldo Cruz
;
100(1): 85-89, Feb. 2005. ilus
Artículo
en Inglés
| LILACS
| ID: lil-398122
RESUMO
Anti-human immunodeficiency virus type 1 (HIV-1) "binding antibodies" (antibodies capable of binding to synthetic peptides or proteins) occur throughout HIV-1 infection, are high-titered and highly cross-reactive, as confirmed in this study by analyzing plasma from B and F genotype HIV-1 infected individuals. Plasma from individuals infected with clade F HIV-1 displayed the most frequent cross-reactivity, in high titers, while Bbr plasma showed much higher specificity. Similarly, neutralization of a reference HIV-1 isolate (HIV-1 MN) was more frequently observed by plasma from F than B genotype infected individuals. No significant difference was seen in neutralization susceptibility of primary B, Bbr or F clade HIV-1 by plasma from individuals infected with the classical B (GPGR) or F HIV-1, but Bbr (GWGR) plasma were less likely to neutralize the F genotype primary HIV-1 isolates. The data indicate that both B and F genotype derived vaccines would be equally effective against B and F HIV-1 infection, with a slightly more probable effectiveness for F than B genotype. Although the Bbr variant appears to induce a much more specific humoral immune response, the susceptibility in neutralizing the Brazilian HIV-1 B genotype Bbr variant is similar to that observed with the classical B genotype HIV-1.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Fragmentos de Péptidos
/
Anticuerpos Anti-VIH
/
Antígenos VIH
/
VIH-1
/
Especificidad de Anticuerpos
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2005
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
Institución/País de afiliación:
Centro de Informações Científicas e Tecnológicas-Fiocruz/BR
/
Instituto Oswaldo Cruz-Fiocruz/BR
/
Instituto de Pesquisa Evandro Chagas-Fiocruz/BR
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