Lipoxin agonists: turn right! to path of resolving neutrophil
Mem. Inst. Oswaldo Cruz
;
100(supl.1): 55-57, Mar. 2005. ilus
Artículo
en Inglés
| LILACS
| ID: lil-402176
ABSTRACT
An impressive array of cellular and molecular adaptive responses achieves homeostasis. The inflammatory reaction is an adaptive response triggered by an insult to culminate into the overt cardinal signs of inflammation, eventually leading to resolution and returning the organism back to its original centered state. This article focuses on some aspects of the lipoxin A4 signaling pathway during the resolution phase, to better understand molecular mechanisms by which a neutrophil directs an inflammatory reaction to switch off and resume homeostasis. Defining the resolution state of a neutrophil at the molecular level will aid in treatments of diseases that are associated with an exaggerated and uncontrolled inflammation.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Antiinflamatorios no Esteroideos
/
Mediadores de Inflamación
/
Lipoxinas
/
Homeostasis
/
Neutrófilos
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2005
Tipo del documento:
Artículo
País de afiliación:
Estados Unidos
Institución/País de afiliación:
Harvard Medical School/US
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