Hemopressin: a novel bioactive peptide derived from the alpha1-chain of hemoglobin
Mem. Inst. Oswaldo Cruz
;
100(supl.1): 105-106, Mar. 2005. ilus
Artículo
en Inglés
| LILACS, SES-SP
| ID: lil-402183
ABSTRACT
Hemopressin (PVNFKFLSH), a novel bioactive peptide derived from the alpha1-chain of hemoglobin, was originally isolated from rat brain homogenates. Hemopressin causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE). Hemopressin also exerts an antinociceptive action in experimental inflammatory hyperalgesia induced by carrageenin or bradykinin via a mechanism that is independent of opioids. These findings suggest that this peptide may have important regulatory physiological actions in vivo.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Fragmentos de Péptidos
/
Hemoglobinas
/
Hiperalgesia
/
Analgésicos
/
Hipotensión
Límite:
Animales
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Año:
2005
Tipo del documento:
Artículo
Institución/País de afiliación:
Instituto Butantan/BR
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