Role of protease-activated receptor-2 in inflammation, and its possible implications as a putative mediator of periodontitis
Mem. Inst. Oswaldo Cruz
;
100(supl.1): 177-180, Mar. 2005. ilus
Artículo
en Inglés
| LILACS
| ID: lil-402196
RESUMO
Proteinase-activated receptor-2 (PAR2) belongs to a novel subfamily of G-protein-coupled receptors with seven-transmembrane domains. This receptor is widely distributed throughout the body and seems to be importantly involved in inflammatory processes. PAR2 can be activated by serine proteases such as trypsin, mast cell tryptase, and bacterial proteases, such as gingipain produced by Porphyromonas gingivalis. This review describes the current stage of knowledge of the possible mechanisms that link PAR2 activation with periodontal disease, and proposes future therapeutic strategies to modulate the host response in the treatment of periodontitis.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Periodontitis
/
Receptores Proteinasa-Activados
Límite:
Humanos
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2005
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Canadá
Institución/País de afiliación:
Alberta Heritage Foundation for Medical Research Scholar/CA
/
Universidade Estadual de São Paulo/BR
/
University of Calgary/CA
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