Your browser doesn't support javascript.
loading
The prima donna of epigenetics: the regulation of gene expression by DNA methylation
Santos, K. F; Mazzola, T. N; Carvalho, H. F.
Afiliación
  • Santos, K. F; Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Biologia Celular. Campinas. BR
  • Mazzola, T. N; Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Biologia Celular. Campinas. BR
  • Carvalho, H. F; Universidade Estadual de Campinas. Instituto de Biologia. Departamento de Biologia Celular. Campinas. BR
Rev. bras. pesqui. méd. biol ; Braz. j. med. biol. res;38(10): 1531-1541, Oct. 2005.
Article en En | LILACS | ID: lil-409269
Biblioteca responsable: BR1.1
RESUMO
This review focuses on the mechanisms of DNA methylation, DNA methylation pattern formation and their involvement in gene regulation. Association of DNA methylation with imprinting, embryonic development and human diseases is discussed. Furthermore, besides considering changes in DNA methylation as mechanisms of disease, the role of epigenetics in general and DNA methylation in particular in transgenerational carcinogenesis, in memory formation and behavior establishment are brought about as mechanisms based on the cellular memory of gene expression patterns.
Asunto(s)
Texto completo: 1 Índice: LILACS Asunto principal: Metilación de ADN / Silenciador del Gen / Patrón de Herencia / Epigénesis Genética / Neoplasias Límite: Animals / Humans Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Asunto de la revista: BIOLOGIA / MEDICINA Año: 2005 Tipo del documento: Article / Congress and conference
Texto completo: 1 Índice: LILACS Asunto principal: Metilación de ADN / Silenciador del Gen / Patrón de Herencia / Epigénesis Genética / Neoplasias Límite: Animals / Humans Idioma: En Revista: Braz. j. med. biol. res / Rev. bras. pesqui. méd. biol Asunto de la revista: BIOLOGIA / MEDICINA Año: 2005 Tipo del documento: Article / Congress and conference