The prima donna of epigenetics: the regulation of gene expression by DNA methylation
Rev. bras. pesqui. méd. biol
; Braz. j. med. biol. res;38(10): 1531-1541, Oct. 2005.
Article
en En
| LILACS
| ID: lil-409269
Biblioteca responsable:
BR1.1
RESUMO
This review focuses on the mechanisms of DNA methylation, DNA methylation pattern formation and their involvement in gene regulation. Association of DNA methylation with imprinting, embryonic development and human diseases is discussed. Furthermore, besides considering changes in DNA methylation as mechanisms of disease, the role of epigenetics in general and DNA methylation in particular in transgenerational carcinogenesis, in memory formation and behavior establishment are brought about as mechanisms based on the cellular memory of gene expression patterns.
Texto completo:
1
Índice:
LILACS
Asunto principal:
Metilación de ADN
/
Silenciador del Gen
/
Patrón de Herencia
/
Epigénesis Genética
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Revista:
Braz. j. med. biol. res
/
Rev. bras. pesqui. méd. biol
Asunto de la revista:
BIOLOGIA
/
MEDICINA
Año:
2005
Tipo del documento:
Article
/
Congress and conference