The prima donna of epigenetics: the regulation of gene expression by DNA methylation
Braz. j. med. biol. res
;
38(10): 1531-1541, Oct. 2005.
Artículo
en Inglés
| LILACS
| ID: lil-409269
RESUMO
This review focuses on the mechanisms of DNA methylation, DNA methylation pattern formation and their involvement in gene regulation. Association of DNA methylation with imprinting, embryonic development and human diseases is discussed. Furthermore, besides considering changes in DNA methylation as mechanisms of disease, the role of epigenetics in general and DNA methylation in particular in transgenerational carcinogenesis, in memory formation and behavior establishment are brought about as mechanisms based on the cellular memory of gene expression patterns.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Metilación de ADN
/
Silenciador del Gen
/
Patrón de Herencia
/
Epigénesis Genética
/
Neoplasias
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
2005
Tipo del documento:
Artículo
/
Congreso y conferencia
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Estadual de Campinas/BR
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