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Resistance to reinfection in rats induced by irradiated metacercariae of Clonorchis sinensis
Quan, Fu Shi; Lee, Jeong Beom; Bae, Jun Sang; Ohwatari, Nobu; Min, Young Ki; Yang, Hun Mo.
  • Quan, Fu Shi; Emory University. School of Medicine. Microbiology and Immunology. Atlanta. US
  • Lee, Jeong Beom; Emory University. School of Medicine. Microbiology and Immunology. Atlanta. US
  • Bae, Jun Sang; Soonchunhyang University. College of Medicine. Department of Physiology. Cheonan. KR
  • Ohwatari, Nobu; Nagasaki University. Institute of Tropical Medicine. Department of Environmental Physiology. Nagasaki. JP
  • Min, Young Ki; Soonchunhyang University. College of Medicine. Department of Physiology. Cheonan. KR
  • Yang, Hun Mo; Soonchunhyang University. College of Medicine. Department of Physiology. Cheonan. KR
Mem. Inst. Oswaldo Cruz ; 100(5): 549-554, Aug. 2005. graf
Artículo en Inglés | LILACS | ID: lil-409974
RESUMO
A study was made to observe the association between the resistance to reinfection induced by irradiated metacercariae (MC) of Clonorchis sinensis and antigen specific Th1- and Th2-type cytokine productions in rats. Rats were infected with 20 MC of C. sinensis, previously exposed to a single dose of gamma irradiation, which varied from 0 to 100 Gy. All of them, single dose of 12 Gy showed higher IgG antibody titer with lowest worm recovery. Thus, 50 MC were used to challenge infection in rats previously infected with 20 MC irradiated at 12 Gy and the highest resistance to challenge infection was observed. The results of lymphocyte proliferation with specific antigen, ES Ag were shown no difference of proliferative responses as compared with primary and challenge infection at 12 Gy irradiation dose. In the case of cytokines production were observed that interferon (IFN-gamma) and interlukin (IL-2) were significantly enhanced, while IL-4 and IL-10 was almost unchanged to make comparison between primary and secondary infection at 12 Gy irradiation dose. In conclusion, the single dose of 12 Gy could be adopted for induction of the highest resistance to challenge infection. Up-regulation of Th1 type cytokines, IFN-gamma and IL-2 may be affected to develop vaccine by irradiated MC.
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Citocinas / Clonorquiasis / Clonorchis sinensis Límite: Animales Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 2005 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Japón / Corea del Sur / Estados Unidos Institución/País de afiliación: Emory University/US / Nagasaki University/JP / Soonchunhyang University/KR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Citocinas / Clonorquiasis / Clonorchis sinensis Límite: Animales Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 2005 Tipo del documento: Artículo / Documento de proyecto País de afiliación: Japón / Corea del Sur / Estados Unidos Institución/País de afiliación: Emory University/US / Nagasaki University/JP / Soonchunhyang University/KR