Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans
Mem. Inst. Oswaldo Cruz
;
100(3): 325-330, May 2005. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-411033
ABSTRACT
Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 æM benznidazole induced an increasing of mitotic recombination events in diploid strain. Results were related to the induction of chromosomal breaks by the antiparasitic drug.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Aspergillus nidulans
/
Diploidia
/
Mutágenos
/
Nitroimidazoles
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2005
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Estadual de Maringá/BR
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