Resorbable extracellular matrix grafts in urologic reconstruction
Int. braz. j. urol
;
31(3): 192-203, May-June 2005. ilus
Artículo
en Inglés
| LILACS
| ID: lil-411093
RESUMO
PURPOSE:
There is an increasingly large body of literature concerning tissue-engineering products that may be used in urology. Some of these are quite complex (such as multilayer patient-specific cell-seeded implants) yet the most simple and successful products to date are also the most uncomplicated resorbable acellular extra-cellular matrices (ECMs) harvested from animals. ECMs have been used in a variety of difficult urologic reconstruction problems, and this review is intended to summarize this complex literature for the practicing urologist.METHODS:
Medline search of related terms such as "SIS, small intestinal submucosa, ECM, extracellular matrix, acellular matrix and urologic reconstruction". Manuscripts missed in the initial search were taken from the bibliographies of the primary references.RESULTS:
Full review of potential clinical uses of resorbable extra-cellular matrices in urologic reconstruction.CONCLUSIONS:
Currently, the "state of the art" in tissue engineering solutions for urologic reconstruction means resorbable acellular xenograft matrices. They show promise when used as a pubovaginal sling or extra bolstering layers in ureteral or urethral repairs, although recent problems with inflammation following 8-ply pubovaginal sling use and failures after 1- and 4-ply SIS repair of Peyronie's disease underscore the need for research before wide adoption. Preliminary data is mixed concerning the potential for ECM urethral patch graft, and more data is needed before extended uses such as bladder augmentation and ureteral replacement are contemplated. The distant future of ECMs in urology likely will include cell-seeded grafts with the eventual hope of producing "off the shelf" replacement materials. Until that day arrives, ECMs only fulfill some of the requirements for the reconstructive urologist.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Procedimientos Quirúrgicos Urológicos
/
Enfermedades Urológicas
/
Ingeniería de Tejidos
/
Matriz Extracelular
/
Mucosa Intestinal
Límite:
Animales
/
Femenino
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Int. braz. j. urol
Asunto de la revista:
Urología
Año:
2005
Tipo del documento:
Artículo
País de afiliación:
Estados Unidos
Institución/País de afiliación:
Wayne State University School of Medicine/US
Similares
MEDLINE
...
LILACS
LIS