Molecular biology and genetics affecting pediatric solid tumors
Bol. Asoc. Méd. P. R
;
92(4/8): 72-82, Apr.-Aug. 2000.
Artículo
en Inglés
| LILACS
| ID: lil-411269
RESUMO
Since the discovery of oncogenes more than 20 years ago, it has been proven that cancer is a genetically determined disease. Multiple genetic alteration occurs during the course of an illness for neoplasia to develop. Transformation of positive cell growth regulators (oncogenes) and inactivations of negative cell growth regulators (tumor suppressor genes) merge to express a malignant phenotype. These genetic alterations occur as chromosomal translocations, deletions, inversion, amplification or point mutation. The objective of this review is to introduce basic concepts of molecular biology and describe the molecular genetics and biologic clinical findings of the most important solid malignant tumors in children, namely Neuroblastoma, Wilms and Rhabdomyosarcoma. It is the oncology surgeons responsibility to learn basic molecular genetics and tumor biology to provide rational and appropriate care in the setting of multidisciplinary management. Identifications of new oncogenes will continue to be important milestones in diagnosis, early detection of tumor recurrence, and as potential targets for gene therapy. Fusion proteins generated by mutated translocations are true tumor specific antigens and potential targets for therapy. The predicament is that they are proteins needing therapeutic manipulation within the tumor cell nuclei. Technological advances in molecular and genetics will develop tools necessary to manipulate the cell nuclear DNA and target cancer cell
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Índice:
LILACS (Américas)
Asunto principal:
Rabdomiosarcoma
/
Tumor de Wilms
/
Neoplasias Renales
/
Neuroblastoma
Tipo de estudio:
Estudio pronóstico
/
Estudio de tamizaje
Límite:
Adolescente
/
Niño
/
Humanos
Idioma:
Inglés
Revista:
Bol. Asoc. Méd. P. R
Asunto de la revista:
Medicina
Año:
2000
Tipo del documento:
Artículo
País de afiliación:
Puerto Rico
Institución/País de afiliación:
University of Puerto Rico/PR
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