Excellent response to interferon therapy in a patient with hypereosinophilic syndrome and elevated serum immunoglobulin E levels
Bol. Asoc. Méd. P. R
;
92(4/8): 59-62, Apr.-Aug. 2000.
Artículo
en Inglés
| LILACS
| ID: lil-411272
ABSTRACT
The hypereosinophilic syndrome (HES) is a heterogeneous disease characterized by sustained eosinophilia for a period of at least six months with evidence of organ involvement. Its manifestations range from a benign disorder not requiring any therapy to an aggressive, malignant variety refractory to common treatments. Diverse therapies have been used, including steroids, hydroxyurea, and chemotherapy, with variable responses. Recently alpha-interferon therapy has been shown effective in this disorder. Of the various prognostic factors, elevated serum immunoglobulin E (IgE) levels is considered among the most favorable, with most patients presenting with a [quot ]benign[quot ] disorder, not requiring therapy. We describe a patient presenting with an aggressive variant of HES despite having elevated IgE levels. The patient had a dramatic and lasting response to alpha-interferon
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Índice:
LILACS (Américas)
Asunto principal:
Interferón-alfa
/
Síndrome Hipereosinofílico
/
Antineoplásicos
Tipo de estudio:
Estudio diagnóstico
/
Estudio pronóstico
Límite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Bol. Asoc. Méd. P. R
Asunto de la revista:
Medicina
Año:
2000
Tipo del documento:
Artículo
País de afiliación:
Puerto Rico
Institución/País de afiliación:
University of Puerto Rico/PR
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