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Morphological and proliferative analysis of the healing tissue in human alveolar sockets covered or not by an e-PTFE Membrane: a preliminary immunohistochemical and ultrastructural study
Penteado, Renata Penteado; Romito, Giuseppe Alexandre; Pustiglioni, Francisco Emílio Pustiglioni; Marques, Márcia Martins Marques.
  • Penteado, Renata Penteado; University of São Paulo. School of Dentistry. São Paulo. BR
  • Romito, Giuseppe Alexandre; University of São Paulo. School of Dentistry. São Paulo. BR
  • Pustiglioni, Francisco Emílio Pustiglioni; University of São Paulo. School of Dentistry. São Paulo. BR
  • Marques, Márcia Martins Marques; University of São Paulo. School of Dentistry. São Paulo. BR
Braz. j. oral sci ; 4(12): 664-669, Jan.-Mar. 2005. ilus, tab
Artículo en Inglés | LILACS, BBO | ID: lil-412434
RESUMO
Healing tissues of extraction sockets have been used, as autografts, for the treatment of periodontal bony defects. These tissues have proved to be more effective in inducing bone formation than mature bone. However, there are limited data regarding the nature andproliferative activity of its cells. The aim of this pilot study was to analyze the nature and the proliferative activity of cells present in newly formed tissue from human extraction sockets, covered or notby an e-PTFE membrane. The healing tissue of 6 pairs from human alveolar sockets covered or not by an e-PTFE membrane, collected 4 weeks after tooth extraction was analyzed. The specimens were observed using light and transmission electron microscopy (TEM). The immunohistochemical characterization of the tissues included type I collagen, osteonectin and bone sialoprotein detection. The proliferation rates of the tissues were obtained using PCNA labeling. Cells and extracellular matrix were labeled for type I collagen,osteonectin and bone sialoprotein, in both groups. PCNA antibodies revealed significant higher proliferation rates in the coronal areas than in the apical areas of the tissues, independent of which group they belonged to. TEM showed cells containing a Golgi apparatus, rough endoplasmic reticulum and mitochondria indicative of secretory cells, in both groups. In the apical area of the test and control groups, the extracellular matrix exhibited more bundles of collagen fibrils thanin the coronal area. The cells of healing tissue of dental sockets are osteoblastic in nature. Additionally, they present higher proliferating rates in the coronal areas, independent of the use of the e-PTFE membrane
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Índice: LILACS (Américas) Asunto principal: Regeneración Ósea / Regeneración Tisular Dirigida Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Braz. j. oral sci Asunto de la revista: Odontología Año: 2005 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: University of São Paulo/BR

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Índice: LILACS (Américas) Asunto principal: Regeneración Ósea / Regeneración Tisular Dirigida Límite: Femenino / Humanos / Masculino Idioma: Inglés Revista: Braz. j. oral sci Asunto de la revista: Odontología Año: 2005 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: University of São Paulo/BR