Assessment of serum catecholamine concentrations in patients with pheochromocytoma undergoing videolaparoscopic adrenalectomy

ABSTRACT

INTRODUCTION: We analyzed the changes in serum catecholamine concentrations, i.e. adrenaline and noradrenaline, in response to surgical stress in patients with pheochromocytoma who undergone videolaparoscopic adrenalectomy. MATERIALS AND METHODS: Between January 1998 and March 2002, 11 patients underwent 12 videolaparoscopic adrenalectomies. In one case, the adrenalectomy was bilateral. Serum catecholamines were measured at 6 surgical times T0 control before induction; T1 following the induction, laryngoscopy and intubation sequence; T2 after installing the pneumoperitoneum; T3 during manipulation-exeresis of the pheochromocytoma; T4 following ablation of the pheochromocytoma; T5 in the recovery room following intervention when the patient was extubated and was hemodynamically stable. RESULTS: Mean concentrations of serum noradrenaline were significantly different when the T0 and T2 surgical times were compared (T0 3161 pg/mL; T2 40440 pg/mL; p < 0.01), T0 and T3 (T0 3161 pg/mL; T3 46021 pg/mL; p < 0.001), T1 and T3 (T1 5531 pg/mL; T3 46021 pg/mL; p < 0.01), T2 and T4 (T2 40440 pg/mL; T4 10773 pg/mL; p < 0.01) and T3 and T5 (T3 46021 pg/mL; T5 2549 pg/mL; p < 0.001). Mean concentrations of serum adrenaline were significantly different when the T0 and T3 surgical times were compared (T0 738 pg/mL; T3 27561 pg/mL; p < 0.01). CONCLUSION: The pneumoperitoneum significantly increases serum noradrenaline concentrations, manipulation of the adrenal gland significantly increases the serum concentrations of noradrenaline and adrenaline, and the pheochromocytoma ablation significantly decreases serum noradrenaline concentrations.