Heterologous protein production and delivery systems for Lactococcus lactis
Genet. mol. res. (Online)
;
2(1): 102-111, Mar. 2003.
Artículo
en Inglés
| LILACS
| ID: lil-417620
RESUMO
Lactic acid bacteria (LAB), widely used in the food industry, are present in the intestine of most animals, including humans. The potential use of these bacteria as live vehicles for the production and delivery of heterologous proteins of vaccinal, medical or technological interest has therefore been extensively investigated. Lactococcus lactis, a LAB species, is a potential candidate for the production of biologically useful proteins. Several delivery systems have been developed to target heterologous proteins to a specific cell location (i.e., cytoplasm, cell wall or extracellular medium). A promising application of L. lactis is its use as an antigen delivery vehicle, for the development of live mucosal vaccines. The expression of heterologous proteins and antigens as well as the various delivery systems developed in L. lactis, and its use as an oral vaccine carrier are discussed
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Vacunas
/
Lactococcus lactis
/
Vectores Genéticos
Límite:
Animales
Idioma:
Inglés
Revista:
Genet. mol. res. (Online)
Asunto de la revista:
Biologia Molecular
/
Genética
Año:
2003
Tipo del documento:
Artículo
País de afiliación:
Francia
Institución/País de afiliación:
Institut National de la Recherche Agronomique/FR
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