Micellar solubilization of ibuprofen - influence of surfactant head groups on the extent of solubilization
RBCF, Rev. bras. ciênc. farm. (Impr.)
; 41(2): 237-246, abr.-jun. 2005. tab, graf
Article
en En
| LILACS
| ID: lil-420705
Biblioteca responsable:
BR40.1
RESUMO
An important property of micells with particular significance in pharmacy is their ability to increase the solubility of poorly soluble drugs in water, thus increasing their bioavailability. In this work, the solubilization of ibuprofen (IBU) was studied in micellar solutions of there surfactants possessing the same hydrocarbon tail but different hydrophilic head groups, namely sodium dodecyl sulphate (SDS), dodecyltrimethylammonium bromide (DTAB), and n-dodecyl octa(ethylene oxide) (`C IND. 12´ E`O IND. 8´). The results showed that, irrespective of the surfactant type, the solubility of IBU increased linearly with increasing surfactant concentration, as a consequence of the association between the drug and the micelles...
Texto completo:
1
Índice:
LILACS
Asunto principal:
Dodecil Sulfato de Sodio
/
Ibuprofeno
Idioma:
En
Revista:
RBCF, Rev. bras. ciênc. farm. (Impr.)
Asunto de la revista:
BIOQUIMICA
/
FARMACIA
/
FARMACOLOGIA
Año:
2005
Tipo del documento:
Article