Ranitidine treatment inducing methemoglobinemia in male Wistar rats
RBCF, Rev. bras. ciênc. farm. (Impr.)
;
41(2): 247-252, abr.-jun. 2005. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-420706
RESUMO
Drug idiosyncrasy is an adverse event of unknown etiology that occurs in a small fraction of people taking a drug. The histamine-2(H2)-receptor antagonist ranitidine causes idiosyncratic reactions in patients. To investigative the hypothesis that ranitidine could induce hematological toxic effects, the drug was administered intraperitoneally(ip) to two of six groups of 200-220 g male Wistar rats (n=6). Group I received as single dose of saline solution (NaCl, 200 µL) Group II received 200 µL of NaCl, ip, at 0, 24, 48 and 72 h, Group III (controls of the vehicle) received as single dose of dimethyl sulfoxide (DMSO, 200 µL), ip, Group IV (controls of the vehicle) received 200 µL of DMSO, ip, at 0, 24, 48, and 72 h, Group V received a single dose of 100 mg/kg of ranitidine in 200 µL of DMSO) ip, Group VI received 50 mg/kg of ranitidine, in 200 µL of DMSO, ip, at 0, 24, 48, and 72 h...
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Ranitidina
/
Idiosincrasia
/
Metahemoglobinemia
Límite:
Animales
Idioma:
Inglés
Revista:
RBCF, Rev. bras. ciênc. farm. (Impr.)
Asunto de la revista:
Bioquímica
/
Farmacia
/
Farmacología
Año:
2005
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade de São Paulo/BR
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