Biochemical changes and manifestations of envenomation produced by Odonthobuthus doriae venom in rabbits
J. venom. anim. toxins incl. trop. dis
;
12(1): 67-77, 2006. tab, ilus
Artículo
en Inglés
| LILACS, VETINDEX
| ID: lil-423835
RESUMO
Many toxins from scorpion venoms cause neurotransmitters release by activating the autonomic system. The aim of the present work was to determine osmotic fragility of red blood cells (RBCs) and serum biochemical changes produced by the venom of Odonthobuthus doriae (O. doriae), a dangerous species of scorpion in Iran. For this study we selected 2 groups, each one containing 10 New Zealand white rabbits weighing 2 ± 0.2 kg. In vivo and in vitro osmotic fragilities as well as packed cell volume (PCV) were determined. Serum was separated and used for determination of glucose, blood urea nitrogen (BUN), creatinine, uric acid (UA), triglycerides, cholesterol, aspartate aminotransferase (AST, EC 2.6.1.1), and alanine aminotransferase (ALT, EC 2.6.1.2). Results indicate that Odonthobuthus doriae venom (0.5 mg/kg, IV) causes a significant increase (p<0.05) of serum glucose, UA, PCV, ALT, and AST. Increase was also observed in BUN, but it was not statistically significant. On the other hand a significant decrease (p<0.05) was observed in triglycerides and cholesterol levels. Increased in vivo osmotic fragility of RBCs was significant too, but in vitro osmotic fragility did not show a significant change. These results support the hypothesis that the biochemical variation caused by scorpion venom can be due to an autonomic storm and release of catecholamines.(AU)
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Venenos de Escorpión
/
Fenómenos Bioquímicos
/
Nitrógeno de la Urea Sanguínea
/
Técnicas In Vitro
/
Glucosa
Límite:
Animales
Idioma:
Inglés
Revista:
J. venom. anim. toxins incl. trop. dis
Año:
2006
Tipo del documento:
Artículo
Institución/País de afiliación:
Jundishapour University of Medical Sciences/IR
/
Razi Vaccine and Serum Research Institute/IR
/
Shaheed Beheshti University of Medical Sciences/IR
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