Absence of mutagenicity in somatic and germ cells of mice submitted to subchronic treatment with an extract of Croton cajucara Benth. ( Euphorbiaceae )
Genet. mol. biol
;
29(1): 159-165, 2006. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-424753
RESUMO
The plant Croton cajucara Benth. (Euphorbiaceae) is a medicinal plant from the Brazilian Amazon where it is commonly known as sacaca. The principal compound isolated from C. cajucara stem-bark extracts is the clerodane-type diterpene trans-dehydrocrotonin (DCTN) which presents several biological activities, including antiulcerogenic, anti-inflammatory, hypoglycemic, antimutagenic and antitumoral activity. However, few studies have been carried out to evaluate the therapeutic potential of raw C. cajucara extracts. We studied mutagenicity and antimutagenicity effects of C. cajucara methanol extract using the micronucleus assay in bone marrow cells and the dominant lethal assay in mice submitted to subchronic treatments. The blood testosterone levels of the mice were also measured to assess the effects of the methanol extract on testes function. Statistical analysis of the data obtained in this study showed no statistically significant mutagenicity attributable to C. cajucara stem-bark extracts, nor did such extracts show antimutagenic activity at the concentrations assessed. The testosterone concentration was normal in all the mice studied.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Antimutagênicos
/
Croton
Límite:
Animales
Idioma:
Inglés
Revista:
Genet. mol. biol
Asunto de la revista:
Genética
Año:
2006
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Estadual de Londrina/BR
/
Universidade Federal do Rio de Janeiro/BR
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