Kaposi's sarcoma-associated herpesvirus infection and Kaposi's sarcoma in Brazil
Braz. j. med. biol. res
;
39(5): 573-580, May 2006. ilus, tab
Artículo
en Inglés
| LILACS
| ID: lil-425781
RESUMO
Kaposi's sarcoma (KS) became a critical health issue with the emergence of acquired immunodeficiency syndrome (AIDS) in the 1980s. Four clinical-epidemiological forms of KS have been described classical KS, endemic KS, iatrogenic KS, and AIDS-associated KS. In 1994, Kaposi's sarcoma-associated herpesvirus (KSHV) or human herpesvirus type 8 was identified by Chang and colleagues, and has been detected worldwide at frequencies ranging from 80 to 100 percent. The aim of the present study was to evaluate the frequency of KSHV infection in KS lesions from HIV-positive and HIV-negative patients in Brazil, as well as to review the current knowledge about KS transmission and detection. For these purposes, DNA from 51 cases of KS was assessed by PCR 20 (39.2 percent) cases of classical KS, 29 (56.9 percent) of AIDS-associated KS and 2 (3.9 percent) of iatrogenic KS. Most patients were males (7.51, M/F), and mean age was 47.9 years (SD = ± 18.7 years). As expected, HIV-positive KS patients were younger than patients with classical KS. On the other hand, patients with AIDS-associated KS have early lesions (patch and plaque) compared to classical KS patients (predominantly nodular lesions). This is assumed to be the result of the early diagnose of KS in the HIV-positive setting. KSHV infection was detected by PCR in almost all cases (48/51; 94.1 percent), irrespectively of the clinical-epidemiological form of KS. These results show that KSHV is associated with all forms of KS in Brazilian patients, a fact that supports the role of this virus in KS pathogenesis.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Sarcoma de Kaposi
/
ADN Viral
/
Infecciones Oportunistas Relacionadas con el SIDA
Tipo de estudio:
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
America del Sur
/
Brasil
Idioma:
Inglés
Revista:
Braz. j. med. biol. res
Asunto de la revista:
Biologia
/
Medicina
Año:
2006
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Brasil
Institución/País de afiliación:
Consultoria em Patologia/BR
/
Universidade Estatual Paulista/BR
Similares
MEDLINE
...
LILACS
LIS