Local regulation of the axonal phenotype, a case of merotrophism
Biol. Res
;
38(4): 365-374, 2005. ilus
Artículo
en Inglés
| LILACS
| ID: lil-425820
ABSTRACT
In this essay, we show that several anatomical features of the axon, namely, microtubular content, caliber and extension of sprouts, correlate on a local basis with the particular condition of the glial cell, i.e., the anatomy of axons is dynamic, although it is seen usually in its `normal' state. The occurrence of ribosomes and messenger RNAs in the axon suggests that axoplasmic proteins are most likely synthesized locally, at variance with the accepted notion that they are supplied by the cell body. We propose that the supporting cell (oligodendrocyte or Schwann cell) regulates the axonal phenotype by fine-tuning the ongoing axonal protein synthesis.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Células de Schwann
/
Axones
Límite:
Animales
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2005
Tipo del documento:
Artículo
País de afiliación:
Chile
/
Italia
Institución/País de afiliación:
Pontificia Universidad Católica/CL
/
San Raffaele Scientific Institute/IT
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