Efecto de la administración oral de zinc sobre sensibilidad a la insulina y niveles séricos de leptina y andrógenos en hombres con obesidad / Effect of oral zinc administration on insulin sensitivity, leptin and androgens in obese males
Rev. méd. Chile
;
134(3): 279-284, mar. 2006. ilus, tab
Artículo
en Español
| LILACS
| ID: lil-426092
RESUMO
Background:
Zinc is important for insulin synthesis, storage and secretion. When zinc concentration decrease, there is a concomitant reduction in insulin secretion and peripheral insulin sensitivityAim:
To assess the effects of zinc sulfate on insulin sensitivity, leptin and androgens in obese individuals. Material andmethods:
A randomized, double-blind, placebo-controlled clinical trial was performed in 14 obese volunteers between 21 and 30 years old, with body mass index (BMI) ³ 27 kg/m2. During one month, seven subjects received 100 mg/day of zinc sulfate orally (ZnG) and the other seven received placebo, as control group (CG). At baseline and after the intervention, insulin sensitivity was measured using a euglycemic-hyperinsulinemic clamp technique. Blood glucose, serum lipids, zinc, androgens and leptin were also measured in a fasting blood sample.Results:
After the intervention, a rise in zinc concentrations from 11.8 to 16.9 umol/L; p=0.001 and in leptin levels from 15.2 to 27.7 ng/mL; p=0.029, was observed in the ZnG. No changes were observed in the CG. There were no significant changes in insulin sensitivity and androgens after the intervention with zinc sulfate.Conclusions:
Zinc increased the leptin concentrations in obese individuals, but did not modify insulin sensitivity and androgens.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Zinc
/
Resistencia a la Insulina
/
Suplementos Dietéticos
/
Leptina
/
Andrógenos
/
Obesidad
Tipo de estudio:
Ensayo Clínico Controlado
/
Estudio diagnóstico
Límite:
Adulto
/
Humanos
/
Masculino
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2006
Tipo del documento:
Artículo
País de afiliación:
México
Institución/País de afiliación:
Instituto Mexicano del Seguro Social/MX
/
Universidad de Guadalajara/MX
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