Perfil metabólico de riesgo cardiovascular en niños y adolescentes obesos con menor sensibilidad insulínica / Cardiovascular risk and metabolic profile in obese children and adolescents with low insulin sensitivity
Rev. méd. Chile
;
133(7): 795-804, jul. 2005. ilus, tab
Artículo
en Español
| LILACS
| ID: lil-429139
RESUMO
Background:
Infantile obesity is associated with metabolic disturbances (hiperinsulinism, impaired glucose, dislypidemia) that determine a higher risk of type 2 diabetes, high blood pressure and atherosclerotic vascular disease in adulthood. Insulin resistance is a central mechanism of complications of obesity and is associated to body fat mass.Aim:
To investigate insulin sensitivity and its association with anthropometric and metabolic variables in obese children. Patients andmethods:
We studied 314 children aged 6 to 15 years. Of these, 235 had a body mass index (BMI) over the 95 percentile for age and sex (classified as obese) and 79 had a normal body mass index; 161 were pre-pubescent and 153 were pubescent. Weight, height, percentage of total body fat (% TBF) using the sum of 4 skinfolds, blood pressure (BP), waist circumference (WC), basal glucose (Glu) and insulin (Ins) were measured. Insulin sensitivity (IS) was calculated with the homeostasis model assessment (HOMA) and QUICKI index. Serum lipids, postprandial Glu and Ins were measured only in obese children.Results:
BMI, WC and % TBF had an inverse and significant correlation with basal IS (p <0.001). Obese children had higher BP, basal Ins, and HOMA and a lower QUICKI index, compared to normal weight children. A low basal IS was present in 58% of obese children. Obese children with low IS had higher WC, % TBF, triglycerides, total/HDL-cholesterol ratio, basal and 2-h post glucose Gli and Ins and lower HDL-cholesterol than obese children with normal IS. In prepubescent children, the risk of a low IS was 2.43 times higher with a TBF over 33%. In pubescent children, it was 2.92 times higher with a TBF over 37%.Conclusions:
Low IS in prepubescent and pubescent obese children is associated with central obesity and a higher cardiovascular risk.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Resistencia a la Insulina
/
Enfermedades Cardiovasculares
/
Índice de Masa Corporal
/
Síndrome Metabólico
/
Obesidad
Tipo de estudio:
Estudio diagnóstico
/
Estudio de etiología
/
Estudio observacional
/
Estudio de prevalencia
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Adolescente
/
Niño
/
Femenino
/
Humanos
/
Masculino
Idioma:
Español
Revista:
Rev. méd. Chile
Asunto de la revista:
Medicina
Año:
2005
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Universidad de Chile/CL
Similares
MEDLINE
...
LILACS
LIS