Changes in crossover distribution along a quadrivalent in aman carrier of a reciprocal translocation t(11; 14)
Biocell
;
29(2): 195-203, ago. 2005. ilus, tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-429675
ABSTRACT
A testicu1ar biopsy from an infertile man carrying a heterozygous chromosome translocation t(ll; 14) was studied with synaptonemal complex analysis and immunolocalization of the protein MLH 1 for crossover detection. A full blockage of spermatogenesis at the spermatocyte stage was related to the presence of the translocation quadrivalents at pachytene. Only 2% of the quadrivalents showed full synapsis. Most of the spermatocytes showed asynaptic free ends that frequently mingled with the XY pair. The average number of crossovers per cell was diminished from a mean of 52.7 in controls to a mean of 48 in the patient. The difference between the number of crossovers in the quadrivalent and the normal bivalents was highly significant. The distribution of crossovers over the segment of the quadrivalent corresponding to bivalent #14 was also very different from that ofthe control. It is concluded that in this translocation, the pattern of crossovers is changed, mainly due to a synaptic hindrance in the quadrivalent, and that the spermatogenesis arrest is mainly due to the quadrivalents that interact with the XY pair
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Índice:
LILACS (Américas)
Asunto principal:
Espermatogénesis
/
Infertilidad Masculina
/
Meiosis
Tipo de estudio:
Estudio diagnóstico
Límite:
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Biocell
Asunto de la revista:
Clulas
Año:
2005
Tipo del documento:
Artículo
País de afiliación:
Argentina
Institución/País de afiliación:
Universidad Nacional de Buenos Aires/AR
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