Iron and glutathione at the crossroad of redox metabolism in neurons
Biol. Res
;
39(1): 157-165, 2006. ilus
Artículo
en Inglés
| LILACS
| ID: lil-430708
RESUMO
Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron-induced oxidative stress is the cause of several forms of neurodegeneration. Here, we review recent evidence that gives support to the following notions 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione. These findings may help to understand aging-related neurodegeneration hallmarks oxidative damage, functional impairment and cell death.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Estrés Oxidativo
/
Glutatión
/
Hierro
/
Degeneración Nerviosa
/
Neuronas
Límite:
Adulto
/
Anciano
/
Humanos
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2006
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Chile
Institución/País de afiliación:
Universidad de Chile/CL
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