Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells
Biol. Res
;
39(1): 189-190, 2006. ilus
Artículo
en Inglés
| LILACS
| ID: lil-430712
RESUMO
Recent evidence suggests that reactive oxygen species function as second messenger molecules in normal physiological processes. For example, activation of N-Methyl-D-Aspartate receptor results in the production of ROS, which appears to be critical for synaptic plasticity, one of the cellular mechanisms that underlie learning and memory. In this work, we studied the effect of iron in the activation of MAPK/ERK pathway and on Ca2+ signaling in neuronal PC12 cells. We found that iron-dependent generation of hydroxyl radicals is likely to modulate Ca2+ signaling through RyR calcium channel activation, which, in turn, activates the MAPK/ERK pathway. These findings underline the relevance of iron in normal neuronal function.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Especies Reactivas de Oxígeno
/
Canal Liberador de Calcio Receptor de Rianodina
/
Quinasas MAP Reguladas por Señal Extracelular
/
Hierro
/
Neuroblastoma
Límite:
Animales
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2006
Tipo del documento:
Artículo
/
Documento de proyecto
País de afiliación:
Chile
Institución/País de afiliación:
Fondap Center for Molecular Studies of the Cell/CL
/
Universidad de Chile/CL
Similares
MEDLINE
...
LILACS
LIS