Detection of hepatitis A, B, and C virus-specific antibodies using oral fluid for epidemiological studies
Mem. Inst. Oswaldo Cruz
; 101(2): 149-155, Mar. 2006. tab
Article
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| LILACS
| ID: lil-430891
Biblioteca responsable:
BR1.1
RESUMO
In this report, we examine the adaptability of commercially available serological kits to detect antibodies markers for viral hepatitis in oral fluid samples. We also assessed the prevalence of hepatitis A, B, and C virus-specific antibodies, and related risk factors for these infectious diseases through sensitivity of the tests in saliva samples to evaluate if oral fluid can be an alternative tool to substitute serum in diagnosis of acute viral hepatitis and in epidemiological studies. One hundred and ten paired serum and saliva specimens from suspect patients of having acute hepatitis were collected to detect antibodies to hepatitis A (total and IgM), hepatitis B (anti-HBs, total anti-HBc and IgM anti-HBc), and hepatitis C (anti-HCV) using commercially available enzyme-linked immunossorbent assay (EIA). In relation to serum samples, oral fluid assay sensitivity and specificity were as follows 87 and 100 percent for total anti-HAV, 79 and 100 percent for anti-HAV IgM, 6 and 95 percent for anti-HBs, 13 and 100 percent for total anti-HBc, 100 and 100 percent for anti-HBc IgM, and 75 and 100 percent for anti-HCV. The consistency observed between antibodies tests in saliva and expected risk factors for hepatitis A and C suggests that the saliva method could replace serum in epidemiological studies for hepatitis A and C.
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Índice:
LILACS
Asunto principal:
Saliva
/
Anticuerpos Antihepatitis
/
Virus de la Hepatitis B
/
Hepacivirus
/
Virus de la Hepatitis A
/
Hepatitis Viral Humana
Tipo de estudio:
Diagnostic_studies
/
Risk_factors_studies
Límite:
Adolescent
/
Adult
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Child
/
Female
/
Humans
/
Male
País/Región como asunto:
America do sul
/
Brasil
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
MEDICINA TROPICAL
/
PARASITOLOGIA
Año:
2006
Tipo del documento:
Article