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Seroepidemiology of hepatitis B virus infection and high rate of response to hepatitis B virus Butang®vaccine in adolescents from low income families in Central Brazil
Oliveira, Michele Dias da S; Martins, Regina M. B; Matos, Marcos A; Ferreira, Renata C; Dias, Márcia A; Carneiro, Megmar A. S; Junqueira, Ana Luiza N; Teles, Sheila A.
  • Oliveira, Michele Dias da S; Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia. BR
  • Martins, Regina M. B; Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia. BR
  • Matos, Marcos A; Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia. BR
  • Ferreira, Renata C; Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia. BR
  • Dias, Márcia A; Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia. BR
  • Carneiro, Megmar A. S; Universidade Federal de Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia. BR
  • Junqueira, Ana Luiza N; Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia. BR
  • Teles, Sheila A; Universidade Federal de Goiás. Faculdade de Enfermagem. Goiânia. BR
Mem. Inst. Oswaldo Cruz ; 101(3): 251-256, May 2006. tab, graf
Artículo en Inglés | LILACS | ID: lil-431721
RESUMO
In order to evaluate the seroepidemiology and response to Butang® vaccine in adolescents from low income families in Central Brazil, blood samples of 664 adolescents were tested for hepatitis B surface antigen (HBsAg), hepatitis B core antibody (anti-HBc), and hepatitis B surface antibody (anti-HBs) markers, and multiple logistical regression analysis was carried out to determine variables associated with hepatitis B virus (HBV) infection markers. further, three 20 µg butang® vaccine doses were offered to all susceptible individuals (n = 304). Among those who accepted them (n = 182), the seroresponse was evaluated in 170 individuals by quantitative anti-HBs. an overall hbv prevalence of 5.9 percent was found four adolescents were HBsAg positive, 24 were anti-HBc, anti-HBs-reactive, and 11 were anti-HBc only. The analyse of risk factors showed that age 16-19 years, place of birth outside Goiás, school B and body piercing were statistically associated with HBV infection markers (p < 0.05). All 170 adolescents responded to butang®, and a geometric mean titer (gmt) of 4344 mui/ml was obtained. these results reinforce the importance of hepatitis b vaccine in adolescents despite of the hbv regional endemicity, and suggest that three doses of 20 µg of the butang® should guarantee protective anti-hbs levels to individuals at a critical time for hepatitis b acquiring such as latter adolescence and adulthood.
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Virus de la Hepatitis B / Vacunas contra Hepatitis B / Hepatitis B / Anticuerpos contra la Hepatitis B / Antígenos del Núcleo de la Hepatitis B / Antígenos de Superficie de la Hepatitis B Tipo de estudio: Estudio diagnóstico / Estudio de etiología / Estudio de prevalencia / Factores de riesgo Límite: Adolescente / Adulto / Femenino / Humanos / Masculino País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 2006 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal de Goiás/BR

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Virus de la Hepatitis B / Vacunas contra Hepatitis B / Hepatitis B / Anticuerpos contra la Hepatitis B / Antígenos del Núcleo de la Hepatitis B / Antígenos de Superficie de la Hepatitis B Tipo de estudio: Estudio diagnóstico / Estudio de etiología / Estudio de prevalencia / Factores de riesgo Límite: Adolescente / Adulto / Femenino / Humanos / Masculino País/Región como asunto: America del Sur / Brasil Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 2006 Tipo del documento: Artículo País de afiliación: Brasil Institución/País de afiliación: Universidade Federal de Goiás/BR