Genetic diversity of â-glucuronidase activity among 14 strains of the dominant human gut anaerobe Ruminococcus gnavus
Genet. mol. biol
;
29(2): 363-366, 2006. tab, graf
Artículo
en Inglés
| LILACS
| ID: lil-432710
RESUMO
Bacterial beta-glucuronidase activity in the gut increases the enterohepatic circulation of toxic compounds and plays a major role in the etiology of colon cancer. Previously, we had found that the gus gene, which codes for beta-glucuronidase in a dominant anaerobic species of the gut microbiota, Ruminococcus gnavus strain E1, is transcribed as part of an operon that includes three ORFs that code for beta-glucoside permeases of the phosphotransferase systems. This genetic organization had never been described. We have now compared beta-glucuronidase activity and the genetic environment of the gus gene in 14 strains of Ruminococcus gnavus. We found that five out of the seven glucuronidase-positive R. gnavus strains possessed another glucuronidase gene different from the gusA operon of R. gnavus E1. This dominant commensal intestinal species appears to have a high degree of genetic diversity in the genes that control beta-glucuronidase activity.
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Índice:
LILACS (Américas)
Asunto principal:
Variación Genética
/
Ruminococcus
/
Glucuronidasa
/
Intestinos
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Genet. mol. biol
Asunto de la revista:
Genética
Año:
2006
Tipo del documento:
Artículo
País de afiliación:
Brasil
/
Francia
Institución/País de afiliación:
Institut National de la Recherche Agronomique/FR
/
Universidade Federal de Minas Gerais/BR
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