Biochemical and biological properties of Lonomia obliqua bristle extract
J. venom. anim. toxins incl. trop. dis
;
12(2): 156-171, 2006. tab
Artículo
en Inglés
| LILACS
| ID: lil-434717
ABSTRACT
Lonomia obliqua caterpillar is frequently seen in accidents with humans especially in the south of Brazil. Patients develop a hemorrhagic syndrome that can be treated with specific antilonomic serum. A consumptive coagulopathy was found to be the main cause of bleeding complications observed in patients after contact with L. obliqua. Studies revealed that L. obliqua caterpillar bristle extract (LOCBE) displays a procoagulant activity that leads to intravascular thrombin formation, resulting in a special form of disseminated intravascular coagulation (DIC). Fibrinolysis seems to be secondary to the fibrin production, since no direct fibrinolytic activity was found in LOCBE. Two procoagulant toxins, a factor X activator (Losac) and a prothrombin activator (Lopap), were isolated from LOCBE and characterized. Infusion of Lopap into experimental animals triggered a condition similar to that observed in human envenomation
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Intoxicación
/
Antivenenos
/
Coagulación Intravascular Diseminada
/
Lepidópteros
/
Mariposas Nocturnas
Límite:
Animales
Idioma:
Inglés
Revista:
J. venom. anim. toxins incl. trop. dis
Asunto de la revista:
Toxicología
Año:
2006
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Butantan Institute/BR
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