Redox regulation of RyR-mediated Ca2+ release in muscle and neurons
Biol. Res
;
37(4): 539-552, 2004. graf
Artículo
en Inglés
| LILACS
| ID: lil-437507
ABSTRACT
Changes in the redox state of the intracellular ryanodine receptor/Ca2+ release channels of skeletal and cardiac muscle or brain cortex neurons affect their activity. In particular, agents that oxidize or alkylate free SH residues of the channel protein strongly enhance Ca2+-induced Ca2+ release, whereas reducing agents have the opposite effects. We will discuss here how modifications of highly reactive cysteine residues by endogenous redox agents or cellular redox state influence RyR channel activation by Ca2+ and ATP or inhibition by Mg2+. Possible physiological and pathological implications of these results on cellular Ca2+ signaling will be addressed as well.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Calcio
/
Músculo Esquelético
/
Canal Liberador de Calcio Receptor de Rianodina
/
Cerebro
/
Miocardio
/
Neuronas
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2004
Tipo del documento:
Artículo
País de afiliación:
Chile
Institución/País de afiliación:
Hospital Clínico de la Universidad de Chile/CL
/
Universidad de Chile/CL
Similares
MEDLINE
...
LILACS
LIS