To be or not to be
nicotinic acid adenine dinucleotide phosphate (NAADP): a new intracellular second messenger?
Biol. Res
;
37(4): 559-563, 2004. ilus
Artículo
en Inglés
| LILACS
| ID: lil-437509
ABSTRACT
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent activator of intracellular Ca2+ release in several vertebrate and invertebrate systems. The role of the NAADP system in physiological processes is being extensively investigated at the present time. The NAADP receptor and its associated Ca2+ pool have been hypothesized to be important in several physiological processes including fertilization, T cell activation, and pancreatic secretion. However, whether NAADP is a new second messenger or a tool for the discovery of a new Ca2+ channel is still an unanswered question. Research developed over the last two years has provided some important clues to whether NAADP is or not a physiological cellular messenger. In this short review, I will discuss some of these new findings that are helping us to find an answer to the important question Is NAADP a second messenger or not?.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Sistemas de Mensajero Secundario
/
Calcio
/
NADP
Límite:
Animales
/
Humanos
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2004
Tipo del documento:
Artículo
País de afiliación:
Estados Unidos
Institución/País de afiliación:
Mayo Clinic and Foundation/US
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