IP3 receptors and Ca2+ signals in adult skeletal muscle satellite cells in situ
Biol. Res
;
37(4): 635-639, 2004. ilus
Artículo
en Inglés
| LILACS
| ID: lil-437519
ABSTRACT
In this short article we review muscle satellite cell characteristics and our studies in adult rodent muscle satellite cells in situ. Using confocal laser scanning microscopy and immunocytochemistry, a high level of IP3 receptor (IP3R) immunostaining was detected in satellite cells. These cells were identified by their peripheral position, their size, the shape of their nucleus, the paucity of the apparent cytoplasm, and the immunostaining with specific molecular markers such as a-actinin, the neural cell adhesion molecule (N-CAM) and desmin. High extracellular K+ (60 mM) induced long-lasting Ca2+ signals in satellite cells in situ. We suggest that electrical activity stimulates IP3-associated Ca2+ signals that could act in concert with signaling pathways triggered by growth factors and/or hormones.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Canales de Calcio
/
Receptores Citoplasmáticos y Nucleares
/
Señalización del Calcio
/
Células Satélite del Músculo Esquelético
Tipo de estudio:
Estudio pronóstico
Límite:
Animales
Idioma:
Inglés
Revista:
Biol. Res
Asunto de la revista:
Biologia
Año:
2004
Tipo del documento:
Artículo
País de afiliación:
Chile
/
Francia
/
Estados Unidos
Institución/País de afiliación:
Institut Fédératif de Neurobiologie Alfredt Fessard/FR
/
Smith College/US
/
Universidad de Chile/CL
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