Investigation of single strand conformational alterations of the TP53 gene in epithelial hyperplasias of the breast
Rev. bras. cancerol
;
46(4): 401-406, out.-dez. 2000. tab
Artículo
en Inglés
| LILACS
| ID: lil-438792
ABSTRACT
Generally, benign breast lesions behave as innocuous and limited proliferations, but sometimes they can represent pre-cancerous diseases. The practical importance of epithelial hyperplasias studies is related to their potential for malignant transformation. The TP53 tumor supressor gene suffers the greatest number of mutations in human cancer Using single strand conformational polymorphism, we did a mutation screening in exons 5 to 8 of the TP53 gene in the tumoral tissues of five patients with epithelial hyperplasias of the breast. The obtained results do not show any polymorphism that indicates mutation. The lack of mutation indicates that this gene is not involved in the initial process of malignization, strengthening the hypothesis that mutations on TP53 gene are a late event in the breast carcinogenesis.
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Asunto principal:
Mama
/
Enfermedades de la Mama
/
Neoplasias de la Mama
/
Genes p53
/
Polimorfismo Conformacional Retorcido-Simple
/
Hiperplasia
Límite:
Adulto
/
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Rev. bras. cancerol
Asunto de la revista:
Neoplasmas
Año:
2000
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Associação Paraense de Combate ao Câncer de Mama/BR
/
Universidade Estadual do Pará/BR
/
Universidade Federal da Paraíba/BR
/
Universidade Federal do Pará/BR
/
Universidade de São Paulo/BR
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