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Aspartic protease activities of schistosomes cleave mammalian hemoglobins in a host-specific manner
Koehler, Jeffrey W; Morales, Maria E; Shelby, Bryan D; Brindley, Paul J.
  • Koehler, Jeffrey W; Tulane University Health Sciences Center. New Orleans. US
  • Morales, Maria E; Tulane University Health Sciences Center. New Orleans. US
  • Shelby, Bryan D; Tulane University Health Sciences Center. New Orleans. US
  • Brindley, Paul J; Tulane University Health Sciences Center. New Orleans. US
Mem. Inst. Oswaldo Cruz ; 102(1): 83-85, Feb. 2007. ilus
Artículo en Inglés | LILACS | ID: lil-440638
ABSTRACT
We examined the efficiency of digestion of hemoglobin from four mammalian species, human, cow, sheep, and horse by acidic extracts of mixed sex adults of Schistosoma japonicum and S. mansoni. Activity ascribable to aspartic protease(s) from S. japonicum and S. mansoni cleaved human hemoglobin. In addition, aspartic protease activities from S. japonicum cleaved hemoglobin from bovine, sheep, and horse blood more efficiently than did the activity from extracts of S. mansoni. These findings support the hypothesis that substrate specificity of hemoglobin-degrading proteases employed by blood feeding helminth parasites influences parasite host species range; differences in amino acid sequences in key sites of the parasite proteases interact less or more efficiently with the hemoglobins of permissive or non-permissive hosts.
Asunto(s)
Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Schistosoma japonicum / Schistosoma mansoni / Hemoglobinas / Ácido Aspártico Endopeptidasas Límite: Animales / Humanos Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 2007 Tipo del documento: Artículo País de afiliación: Estados Unidos Institución/País de afiliación: Tulane University Health Sciences Center/US

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Texto completo: Disponible Índice: LILACS (Américas) Asunto principal: Schistosoma japonicum / Schistosoma mansoni / Hemoglobinas / Ácido Aspártico Endopeptidasas Límite: Animales / Humanos Idioma: Inglés Revista: Mem. Inst. Oswaldo Cruz Asunto de la revista: Medicina Tropical / Parasitología Año: 2007 Tipo del documento: Artículo País de afiliación: Estados Unidos Institución/País de afiliación: Tulane University Health Sciences Center/US