Characterization of the gene expression related to the process of DNA damage tolerance in Schistosoma mansoni
Mem. Inst. Oswaldo Cruz
;
101(supl.1): 157-160, Oct. 2006. ilus
Artículo
en Inglés
| LILACS
| ID: lil-441241
ABSTRACT
In the course of its complex life cycle, the parasite Schistosoma mansoni need to adapt to distinct environments, and consequently is exposed to various DNA damaging agents. The Schistosoma genome sequencing initiative has uncovered sequences from genes and transcripts related to the process of DNA damage tolerance as the enzymes UBC13, MMS2, and RAD6. In the present work, we evaluate the importance of this process in different stages of the life cycle of this parasite. The importance is evidenced by expression and phylogenetic profiles, which show the conservation of this pathway from protozoa to mammalians on evolution.
Texto completo:
Disponible
Índice:
LILACS (Américas)
Asunto principal:
Schistosoma mansoni
/
Daño del ADN
/
ADN de Helmintos
/
Enzimas Ubiquitina-Conjugadoras
Límite:
Animales
Idioma:
Inglés
Revista:
Mem. Inst. Oswaldo Cruz
Asunto de la revista:
Medicina Tropical
/
Parasitología
Año:
2006
Tipo del documento:
Artículo
País de afiliación:
Brasil
Institución/País de afiliación:
Universidade Federal de Uberlândia/BR
/
Universidade de São Paulo/BR
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